MERS-CoV HCoV-EMC/2012滴鼻,口腔，气管，眼途径联合感染狨猴模型

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CoV strain EMC/2012 was performed intranasally (100 µl per nare), orally (500 µl), intratracheally (500 µl) and ocular (50 µl per eye) with DMEM containing 4x106 TCID50 MERSCoV/ml (total dose 5.2x106 TCID50).The hyperimmune plasma and monoclonal antibody groups, consisting of one female and two male common marmosets each, received 1 ml hyperimmune plasma or m336 diluted in PBS (5 mg/ml) intravenous (I.V.) at 6 hpi, and 1 ml hyperimmune plasma or m336 subcutaneous (S.C.) at 2 dpi.

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