MERS-CoV spike-VRP滴鼻感染 MERS-15 C2 288-330+/+小鼠模型
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模型信息
中文名称:MERS-CoV spike-VRP滴鼻感染 MERS-15 C2 288-330+/+小鼠模型
英文名称:MERS-CoV 3B11 post-infection treated MERS-15 intansally infection 288-330+/+ mouse model
类型:MERS-CoV感染动物模型
分级:NA
用途:用于MERS-CoV感染研究。
研制单位:北卡罗来纳大学教堂山分校@@https://www.unc.edu/
保存单位:北卡罗来纳大学教堂山分校@@https://www.unc.edu/
研究背景
暂无介绍
制备方法
To examine vaccine efficacy in the 288-330+/+/MERS-15 C2 model, mice were vaccinated with Venezuelan equine encephalitis replicon particles (VRPs) expressing MERS-CoV spike protein (spike-VRP), or mock vaccinated with VRPs that express GFP (GFP-VRP), boosted at 4 weeks post prime, and challenged with MERS-15 C2 at 4 weeks post-boost. Mice were administered a prime vaccination of 10μl by footpad injection of either spike-VRP (1×105PFU) or the control GFP-VRP (1×105PFU). Twenty-eight days later mice were boosted with the same dose of their respective VRP strain. At 28 days postboost, all vaccinated mice were challenged with 5×106PFU of MERS-15 clone 2.
评价验证
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生物安全性
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讨论与结论
暂无介绍
注意：因业务调整，暂不接受个人委托测试。
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