SARS-CoV-2 BetaCoV/Wuhan/IVDC-HB-01/2020|EPI_ISL_402119滴鼻感染hACE2转基因小鼠模型

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更新时间：2025-06-15 /

关键词:SARS-CoV-2 BetaCoV/Wuhan/IVDC-HB-01/2020|EPI_ISL_402119滴鼻感染hACE2转基因小鼠模型 /

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模型信息

中文名称:SARS-CoV-2 BetaCoV/Wuhan/IVDC-HB-01/2020|EPI_ISL_402119滴鼻感染hACE2转基因小鼠模型

英文名称:SARS-CoV-2 BetaCoV/Wuhan/IVDC-HB-01/2020|EPI_ISL_402119 intranasally infection transgenic hACE2 mouse model

类型:SARS-CoV-2感染动物模型

分级:NA

用途:用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。

研制单位:中国医学科学院医学实验动物研究所新发再发传染病动物模型研究北京市重点实验室@@https://www.natureindex.com/institution-outputs/china/beijing-key-laboratory-for-animal-models-of-emerging-and-remerging-infectious-diseases-cams-pumc/5d6733732521161ac56cb464

保存单位:中国医学科学院医学实验动物研究所新发再发传染病动物模型研究北京市重点实验室@@https://www.natureindex.com/institution-outputs/china/beijing-key-laboratory-for-animal-models-of-emerging-and-remerging-infectious-diseases-cams-pumc/5d6733732521161ac56cb464

研究背景

暂无介绍

制备方法

Mice were inoculated intranasally with SARS-CoV-2 stock virus (HB-01) at a dosage of 10^5 TCID50/50 μl inoculum volume per mouse after the mice were anesthetized by 2.5% avertin, and the mock-treated hACE2 mice(ACE2-Mock) were used as control.