SARS-CoV-2 nCoV-WA1-2020鼻，口，眼，气管感染恒河猴模型

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更新时间：2025-04-30 /

关键词:SARS-CoV-2 nCoV-WA1-2020鼻,口,眼,气管感染恒河猴模型 /

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模型信息

中文名称:SARS-CoV-2 nCoV-WA1-2020鼻，口，眼，气管感染恒河猴模型

英文名称:SARS-CoV-2 nCoV-WA1-2020 intranasal, oral, ocular and intratracheal infected rhesus macaque model

类型:SARS-CoV-2感染动物模型

分级:NA

用途:用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。

研制单位:美国国立卫生研究院过敏与传染病研究所病毒学实验室@@https://www.niaid.nih.gov/research/lab-virology-new

保存单位:美国国立卫生研究院过敏与传染病研究所病毒学实验室@@https://www.niaid.nih.gov/research/lab-virology-new

研究背景

暂无介绍

制备方法

Twelve animals were randomly assigned to two groups and inoculated as described previously with a total dose of 2.6x106 TCID50 of SARS-CoV-2 strain nCoV-WA1-2020 via intranasal, oral, ocular and intratracheal routes. Therapeutic treatment was initiated at 12 hours after inoculation with SARS-CoV-2 and continued once daily through 6 days post inoculation (dpi). One group of rhesus macaques was treated with a loading dose of 10mg/kg remdesivir, followed by a daily maintenance dose of 5 mg/kg.